Figure 1

Structure of cellulose degradome in C. cellulolyticum. (A) Hierarchical clustering analysis of 650 genes that exhibit substrate-specific gene expression under glucose (Glu), cellobiose (Ceb), and cellulose (Cel). A Row Z-Score measures the relationship between the NTA of a gene under a given condition and the mean NTA of the gene under the multiple conditions compared (i.e. the row). A Row Z-score of 0 means the NTA is equal to the mean NTA. Positive (or negative) Row Z-score indicates the degree to which the NTA is higher (or lower) than the mean. The corresponding classes (C1, C2 or C3) were indicated. (B) Functional profiles of the genes that exhibit substrate-specific gene expression. Those GO terms specifically enriched or depleted in the cellulose-specific degradome were shown (0005840: ribosome; 0044444: cytoplasmic part; 0003677: DNA binding; 0003723: RNA binding; 0016787: hydrolase activity; 0016491: oxidoreductase activity; 0005215: transporter activity; 0044255: cellular lipid metabolic process; 0010467: gene expression; 0046483: heterocycle metabolic process; 0009059: macromolecule biosynthetic process; 0009057: macromolecule catabolic process; 0006807: nitrogen compound metabolic process; 0019538: protein metabolic process).