TY - JOUR AU - Garcia Sanchez, Rosa AU - Hahn-Hägerdal, Bärbel AU - Gorwa-Grauslund, Marie F. PY - 2010 DA - 2010/09/01 TI - Cross-reactions between engineered xylose and galactose pathways in recombinant Saccharomyces cerevisiae JO - Biotechnology for Biofuels SP - 19 VL - 3 IS - 1 AB - Overexpression of the PGM2 gene encoding phosphoglucomutase (Pgm2p) has been shown to improve galactose utilization both under aerobic and under anaerobic conditions. Similarly, xylose utilization has been improved by overexpression of genes encoding xylulokinase (XK), enzymes from the non-oxidative pentose phosphate pathway (non-ox PPP) and deletion of the endogenous aldose reductase GRE3 gene in engineered Saccharomyces cerevisiae strains carrying either fungal or bacterial xylose pathways. In the present study, we investigated how the combination of these traits affect xylose and galactose utilization in the presence or absence of glucose in S. cerevisiae strains engineered with the xylose reductase (XR)-xylitol dehydrogenase (XDH) pathway. SN - 1754-6834 UR - https://doi.org/10.1186/1754-6834-3-19 DO - 10.1186/1754-6834-3-19 ID - Garcia Sanchez2010 ER -