Model characteristics of i TL885. A) Model contents of two S. stipitis (i TL885 and i BB814) and one S. cerevisiae (i MM904). B) Venn diagram showing the number of total, shared and unique reactions in the three yeasts GSMMs. C) Statistics of the number of total reactions, gene-associated reaction and total genes in the seven cellular subsystems. Each reaction (except exchange reactions) in the model was assigned to a single subsystem. Abbreviations: CM (carbohydrate metabolism), LM (lipid metabolism), AM (amino acid metabolism), NM (nucleotide metabolism), CV (cofactors and vitamins metabolism), TR (transport reactions), and EM (energy metabolism).