Skip to main content

Advertisement

Table 3 N. oleoabundans genes involved in catabolic pathways related to peroxisomal fatty acid oxidation, lysosomal lipases, and the regulation of autophagy

From: Transcriptomic analysis of the oleaginous microalga Neochloris oleoabundans reveals metabolic insights into triacylglyceride accumulation

Enzyme encoding gene Log2FC
Peroxisome  
α-oxidation  
2-hydroxyacyl-coa lyase 1 (HACL1, EC: 4.1.-.-) 0.35
Unsaturated fatty acid β-oxidation  
Peroxisomal 2,4-dienoyl-coa reductase (DECR2, EC: 1.3.1.34) 0.21
Δ(3,5)-Δ(2,4)-dienoyl-coa isomerase (ECH1, EC: 5.3.3.-) −0.27
ATP-binding cassette, subfamily D (ALD), member 1 (ABCD1) 0.25
Long-chain acyl-coa synthetase (ACSL, EC: 6.2.1.3) 0.25
Other oxidation  
Peroxisomal 3,2-trans-enoyl-coa isomerase (PECI, EC: 5.3.3.8) 0.59
Carnitine O-acetyltransferase (CRAT, EC: 2.3.1.7) 0.30
NAD + diphosphatase (NUDT12, EC: 3.6.1.22) 0.47
Glycerolipid metabolism  
Triacylglycerol lipase (EC: 3.1.1.3) 0.33
Acylglycerol lipase (MGLL, EC: 3.1.1.23) −0.13
Glycerophospholipid metabolism  
Phospholipase A1 (plda, EC: 3.1.1.32) −1.26
Phospholipase A2 (PLA2G, EC: 3.1.1.4) −0.31
Phospholipase C (plcc, EC: 3.1.4.3) −0.10
Lysosome  
Lipases  
Lysosomal acid lipase (LIPA, EC: 3.1.1.13) −0.48
Lysophospholipase III (LYPLA3, EC: 3.1.1.5) 0.20
Regulation of autophagy  
Unc51-like kinase (ATG1, EC: 2.7.11.1) −0.53
5'-AMP-activated protein kinase, catalytic alpha subunit (snrk1, PRKAA) −0.05
Vacuolar protein 8 (VAC8) 0.13
Beclin 1 (BECN1) −0.59
Phosphatidylinositol 3-kinase (VPS34, EC: 2.7.1.137) −1.26
Phosphoinositide-3-kinase, regulatory subunit 4, p150 (VPS15, EC: 2.7.11.1) 0.11
Autophagy-related protein 3 (ATG3) 0.11
Autophagy-related protein 4 (ATG4) −0.16
Autophagy-related protein 5 (ATG5) −0.27
Autophagy-related protein 7 (ATG7) 0.17
Autophagy-related protein 8 (ATG8) −0.50
Autophagy-related protein 12 (ATG12) −0.58
  1. Negative log2 fold change (Log2FC) values represent up-regulation under nitrogen limitation. All presented fold changes are statistically significant, q value < 0.05.