Table 3 N. oleoabundans genes involved in catabolic pathways related to peroxisomal fatty acid oxidation, lysosomal lipases, and the regulation of autophagy
Enzyme encoding gene | Log2FC |
|---|---|
Peroxisome | Â |
α-oxidation |  |
2-hydroxyacyl-coa lyase 1 (HACL1, EC: 4.1.-.-) | 0.35 |
Unsaturated fatty acid β-oxidation |  |
Peroxisomal 2,4-dienoyl-coa reductase (DECR2, EC: 1.3.1.34) | 0.21 |
Δ(3,5)-Δ(2,4)-dienoyl-coa isomerase (ECH1, EC: 5.3.3.-) | −0.27 |
ATP-binding cassette, subfamily D (ALD), member 1 (ABCD1) | 0.25 |
Long-chain acyl-coa synthetase (ACSL, EC: 6.2.1.3) | 0.25 |
Other oxidation | Â |
Peroxisomal 3,2-trans-enoyl-coa isomerase (PECI, EC: 5.3.3.8) | 0.59 |
Carnitine O-acetyltransferase (CRAT, EC: 2.3.1.7) | 0.30 |
NAD + diphosphatase (NUDT12, EC: 3.6.1.22) | 0.47 |
Glycerolipid metabolism | Â |
Triacylglycerol lipase (EC: 3.1.1.3) | 0.33 |
Acylglycerol lipase (MGLL, EC: 3.1.1.23) | −0.13 |
Glycerophospholipid metabolism | Â |
Phospholipase A1 (plda, EC: 3.1.1.32) | −1.26 |
Phospholipase A2 (PLA2G, EC: 3.1.1.4) | −0.31 |
Phospholipase C (plcc, EC: 3.1.4.3) | −0.10 |
Lysosome | Â |
Lipases | Â |
Lysosomal acid lipase (LIPA, EC: 3.1.1.13) | −0.48 |
Lysophospholipase III (LYPLA3, EC: 3.1.1.5) | 0.20 |
Regulation of autophagy | Â |
Unc51-like kinase (ATG1, EC: 2.7.11.1) | −0.53 |
5'-AMP-activated protein kinase, catalytic alpha subunit (snrk1, PRKAA) | −0.05 |
Vacuolar protein 8 (VAC8) | 0.13 |
Beclin 1 (BECN1) | −0.59 |
Phosphatidylinositol 3-kinase (VPS34, EC: 2.7.1.137) | −1.26 |
Phosphoinositide-3-kinase, regulatory subunit 4, p150 (VPS15, EC: 2.7.11.1) | 0.11 |
Autophagy-related protein 3 (ATG3) | 0.11 |
Autophagy-related protein 4 (ATG4) | −0.16 |
Autophagy-related protein 5 (ATG5) | −0.27 |
Autophagy-related protein 7 (ATG7) | 0.17 |
Autophagy-related protein 8 (ATG8) | −0.50 |
Autophagy-related protein 12 (ATG12) | −0.58 |