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Table 5 Differentially regulated metabolites *

From: Integrated OMICS guided engineering of biofuel butanol-tolerance in photosynthetic Synechocystissp. PCC 6803

Metabolites 24 h 48 h 72 h
Cluster I
  Aspartic acid 4 9 9
  Glycerol 1-phosphate 7 9 6
  3-phosphoglycerate 3 9 3
  Citric acid 2 9 6
  D-allose 9 3 9
  Adenosine 5 9 8
  Urea 1 7 3
Cluster II
  Oxalic acid 0 9 6
  Glycine 0 4 5
  Succinic acid 0 6 6
  L-glutamic acid (dehydrated) 0 9 6
  Isocitric acid 0 6 6
  Myristic acid 0 6 8
  Sucrose 0 6 9
Cluster III
  1,3 Propanediol 6 −6 −6
  L-alanine 3 −3 −9
  Itaconic acid 9 −4 −9
  Spermidine 4 −9 −5
Cluster IV
  Methyl palmitate 9 −5 6
  Talose 9 −4 9
  Benzene-1,2,4-triol 2 −3 6
  Adrenaline 7 −6 9
  Lauric acid 9 −8 7
Cluster V
  L-threonine 7 9 0
  D-malic acid 5 3 0
  L-serine 6 5 0
Cluster VI
  L-pyroglutamic acid −3 −9 −3
  Linoleic acid 7 0 9
  L-(+) lactic acid 2 −6 0
  Pyruvic acid −6 0 9
  3-hydroxypyridine 0 −5 9
  4-hydroxypyridine 0 −3 8
  Malonic acid −5 −3 8
  Caprylic acid −6 0 9
  Octane −2 −5 8
  Glycerol 6 −5 0
  Glyceric acid 8 −9 0
  Uracil −8 6 4
  Putrescine −8 0 2
  Tagatose −5 0 9
  Palmitic acid 0 −6 5
  Methyl stearate −9 9 9
  D-glucose-6-phosphate −3 8 9
  Stearic acid 0 −8 5
  Arachidic acid −3 −8 5
  D-(+) trehalose −3 9 0
  1. * For each time point, three biological replicates of butanol-treated samples were compared with three biological replicates of control, generating 9 ratios. For each ratio, ratio > 1.5 was assigned as “ + 1”, ratio< − 1.5 as “-1”, and −1.5 < ratio < 1.5 as “0”. The sums of the nine ratios for each metabolite at any time point were provided.