Figure 5
From: Strong cellulase inhibitors from the hydrothermal pretreatment of wheat straw
Possible structures of IOS provide a mechanistic interpretation of the strong inhibition of Tr Cel7A. (A) We propose that component oligosaccharides of IOS, XOS and GOS, are the fragments of the xylan backbone and mixed linkage b-glucan, respectively. (B) XOS and GOS mimic the structure of cellulose chain and bind to the active site tunnel of TrCel7A through all 10 glucose unit binding sites. This results in stronger binding than that of cellobiose, which binds to the product sites (+1/+2) only.