TY - JOUR AU - Li, Chenlin AU - Tanjore, Deepti AU - He, Wei AU - Wong, Jessica AU - Gardner, James L. AU - Sale, Kenneth L. AU - Simmons, Blake A. AU - Singh, Seema PY - 2013 DA - 2013/10/25 TI - Scale-up and evaluation of high solid ionic liquid pretreatment and enzymatic hydrolysis of switchgrass JO - Biotechnology for Biofuels SP - 154 VL - 6 IS - 1 AB - Ionic liquid (IL) pretreatment is receiving significant attention as a potential process that enables fractionation of lignocellulosic biomass and produces high yields of fermentable sugars suitable for the production of renewable fuels. However, successful optimization and scale up of IL pretreatment involves challenges, such as high solids loading, biomass handling and transfer, washing of pretreated solids and formation of inhibitors, which are not addressed during the development stages at the small scale in a laboratory environment. As a first in the research community, the Joint BioEnergy Institute, in collaboration with the Advanced Biofuels Process Demonstration Unit, a Department of Energy funded facility that supports academic and industrial entities in scaling their novel biofuels enabling technologies, have performed benchmark studies to identify key challenges associated with IL pretreatment using 1-ethyl-3-methylimidazolium acetate and subsequent enzymatic saccharification beyond bench scale. SN - 1754-6834 UR - https://doi.org/10.1186/1754-6834-6-154 DO - 10.1186/1754-6834-6-154 ID - Li2013 ER -