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Table 2 Top ten scoring reporter metabolites connected to transcriptome changes after inhibitor pulse in the xylose consumption phase

From: Pulsed addition of HMF and furfural to batch-grown xylose-utilizing Saccharomyces cerevisiaeresults in different physiological responses in glucose and xylose consumption phase

Metabolite

Number of neighbors

Pvalue

Reporter metabolites (up)

L-methionine[c]

14

1.2E-06

H(+)[e]

37

1.4E-06

ATP[c]

82

8.8E-07

AMP[c]

38

5.1E-06

Diphosphate[c]

50

6.3E-06

L-cysteine[c]

10

1.7E-04

L-methionine[e]

7

2.2E-04

L-glutamine[c]

16

1.1E-04

Coenzyme A[c]

23

1.5E-04

L-threonine[c]

8

5.0E-04

Reporter metabolites (down)

Trans-2-C16-CoA[c]

4

5.4E-03

Trans-2-C14-CoA[c]

4

5.4E-03

Glycogen[c]

4

5.9E-03

Trans-2-C18-CoA[c]

3

9.5E-03

Trans-3-C16-CoA[c]

3

1.3E-02

Trans-3-C18-CoA[c]

3

1.3E-02

Trans-3-C14-CoA[c]

3

1.3E-02

UDP-glucose[c]

10

2.0E-02

CMP[m]

3

1.6E-02

FAD[m]

5

2.2E-02

  1. [c]: cytosolic; [m]: mitochondrial; [e]: extracellular; CMP: cytidine monophosphate; FAD: flavin adenine dinucleotide; UDP-glucose: uridine diphosphate glucose.