Figure 9

A schematic for the mechanisms by which NPKs regulate CreA repression and hydrolytic enzyme production. Upon growth on cellulose as a sole carbon source, a drop in phosphorylated glucose and RAS-mediated PKA activation, results in the loss of the positive signal for CreA nuclear localisation and repression. Subsequently, the drop in intracellular ATP and an alteration in TOR signalling, results in SchA and SnfA controlling CreA re-localisation and hydrolytic enzyme production. Bold arrows represent experimentally proven, while dotted arrow represent hypothetical, connections.