Table 1 The eleven NPKs that demonstrated reduced growth on AVICEL show a conserved theme in nutrient sensing and cell growth
AspGD | A. nidulans gene name | Yeast best hit | Function |
|---|---|---|---|
AN0038 | AtmA | Tel1 | Phospholipid metabolism, DNA damage, cell polarity, starvation |
AN10485 | Uncharacterised (CbkA) | Cbk1 | RAM signalling, regulates cell morphogenesis |
AN0144 | Uncharacterised (FpkA) | Fpk1 | Regulates endocytosis, sphingolipid synthesis |
AN5666 | MpkA | Slt2 | MAP kinase, germination, polarised growth |
AN6305 | PkaC | Tpk2 | Promotes growth in response to nutrition |
AN6207 | Uncharacterised (PkpA) | Pkp1 | Negative regulation of pyruvate dehydrogenase |
AN10515 | Uncharacterised (PrkA) | Prk1 | Actin filament organisation, endocytosis |
AN5728 | Uncharacterised (SakA) | Sak1 | Upstream activator of SNF1 complex |
AN4238 | SchA | Sch9 | cAMP signalling, role overlaps with Ras/PKA, regulated by TOR complex |
AN7695 | Uncharacterised (SnfA) | Snf1 | Required for transcription of glucose repressed genes |
AN7104 | Uncharacterised (YakA) | Yak1 | Inhibits growth in response to glucose, negatively regulated by Ras/PKA |