TY - JOUR AU - Book, Adam J. AU - Yennamalli, Ragothaman M. AU - Takasuka, Taichi E. AU - Currie, Cameron R. AU - Phillips, George N. AU - Fox, Brian G. PY - 2014 DA - 2014/08/06 TI - Evolution of substrate specificity in bacterial AA10 lytic polysaccharide monooxygenases JO - Biotechnology for Biofuels SP - 109 VL - 7 IS - 1 AB - Understanding the diversity of lignocellulose-degrading enzymes in nature will provide insights for the improvement of cellulolytic enzyme cocktails used in the biofuels industry. Two families of enzymes, fungal AA9 and bacterial AA10, have recently been characterized as crystalline cellulose or chitin-cleaving lytic polysaccharide monooxygenases (LPMOs). Here we analyze the sequences, structures, and evolution of LPMOs to understand the factors that may influence substrate specificity both within and between these enzyme families. SN - 1754-6834 UR - https://doi.org/10.1186/1754-6834-7-109 DO - 10.1186/1754-6834-7-109 ID - Book2014 ER -