Figure 3

The butyrate (butanoate) metabolism in C. acetobutylicum summarizing the formation of acids (acetic and butyric acid) and ABE solvents. The acid formation pathways are represented by dotted lines. The mutants that were used to validate the GSM model are represented in red. (ACK - acetate kinase; PTA - phosphotransacetylase; ADHE - alcohol/aldehyde dehydrogenase; THL - thiolase; ADC - acetoacetate decarboxylase; CTFAB - CoA-transferase; HBD - hydroxybutyryl-CoA dehydrogenase; CRT - crotonase; BCD - butyryl-CoA dehydrogenase; BDHAB - butanol dehydrogenase; PTB - phosphotransbutyrylase; BUK - butyrate kinase).