Figure 6

Graphical representation of the CoreReg procedure. The flux bounds for the unregulated model are identified (Step 1) and regulation is imposed on the model (Step 2) based on fold changes in the transcriptomic data. If the biomass regulation is greater than 2% (Step 3), then flux bounds from the regulated model are compared (Step 4) to their regulatory bounds to identify core sets of reactions. Regulatory effects of the identified core sets are excluded (Step 5), and the previous steps (Steps 2–5) are repeated to identify higher order core sets.