Figure 9

The methanogenesis pathway. Enzymes are shown in blue boxes. Subunits missing in all our datasets (R1, R2, R3, R4, and IN) after search against the KO database at MG-RASTare underlined. Abbreviations used in the figure are Acetyl-Pi: acetyl phosphate; ack: acetate kinase; acs: acetyl-CoA synthetase; cdh: acetyl-CoA decarbonylase/synthase; CO: carbon monoxide; CoA: coenzyme A; CoB: coenzyme B; CoB-S-S-CoM: coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide; F420: coenzyme F420; fmd: formylmethanofuran dehydrogenase; Formyl-H4MPT: 5-formyl-5,6,7,8-tetrahydromethanopterin; Formyl-MF: formylmethanofuran; frh: coenzyme F420 hydrogenase; ftr: formylmethanofuran-tetrahydromethanopterin N-formyltransferase; H4MPT: 5,6,7,8-tetrahydromethanopterin; hdr: heterodisulfide reductase; mch: methenyltetrahydromethanopterin cyclohydrolase; mcr: methyl-coenzyme M reductase; mer: 5,10-methylenetetrahydromethanopterin reductase; Methenyl-H4MPT: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin; Methyl-CoM: methylcoenzyme M; Methylene-H4MPT: 5,10-methylenetetrahydromethanopterin; Methyl-H4MPT: 5-methyl-5,6,7,8-tetrahydromethanopterin; mtd: methylenetetrahydromethanopterin dehydrogenase; mtr: tetrahydromethanopterin S-methyltransferase; ppa: inorganic diphosphatase; pta: phosphate acetyltransferase.