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Table 1 IC 50 (g/L)* for furfural and 5-hydroxymethylfurfural in thermophilic bacteria and ethanologenic microorganisms

From: A comparative multidimensional LC-MS proteomic analysis reveals mechanisms for furan aldehyde detoxification in Thermoanaerobacter pseudethanolicus 39E

Organism Furfural 5-HMF YE (% w/v) Carbon (% w/v) Time (h) Temp (°C) pH Ref.
T. pseudethanolicus 39E 3 2 - 3 0.1 0.7 12 65 7.0 TS
T. pseudethanolicus 39E 3 - 4 2 - 3 0.1 0.7 24 65 7.0 TS
Bacillus coagulans MXL-9 2.5 - 5 5 0.5# 5-10 24 50 7.0 [29]
C. saccharolyticus 1 - 2 1 - 2 0.1 1 16, 40 72 7.0 [30]
Thermoanaerobacterium strain AK17 2 3 0.2 0.4 120 60 6.0 [11]
Tm. thermosaccharolyticum 1.25 1 0.2 1 40 60 7.0 [31]
Thermotoga neapolitana 2 - 4 2 - 4 0.1 1 16, 40 80 7.0 [30]
E. coli LY180 1 - 1.5 nd none 5 48 37 6.5 [23]
E. coli LY180 < 0.4 nd none 5 (xyl) 48 37 6.5 [23]
E. coli LY180 1.5 nd 0.1 5 (xyl) 48 37 6.5 [23]
S. cerevisiae CBS 1200 0.5 < 1 0.3 2 24 26 5.8 [32]
S. cerevisiae NSI 113 2 nd 0.3 1 48 30 5.3 [33]
Z. mobilis ATCC 10988 2 5 0.3 2 24 30 5.6 [32]
  1. *Concentration at which 50% inhibition of growth occurred with furfural and 5-hydroxymethylfurfural (5-HMF). Values determined in this study are highlighted in boldface. #Medium also included 1% tryptone; measured as 50% inhibition of ethanol production; YE, yeast extract; nd, not determined; xyl, xylose; TS, This study.