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Table 3 Proteins downregulated twofold or more by 15 mM furfural ( P ≤0.05)

From: A comparative multidimensional LC-MS proteomic analysis reveals mechanisms for furan aldehyde detoxification in Thermoanaerobacter pseudethanolicus 39E

Locus Fold change Description P-value
Amino acid metabolism   
Teth39_0216 -3.10 Glutamate synthase, homotetrameric 0.000
Teth39_0217 -2.47 Oxidoreductase FAD/NAD(P)-binding domain 0.004
Teth39_0487 -2.15 Alanine racemase 0.038
Teth39_1661 -3.77 Glutamine amidotransferase, class II 0.016
Teth39_2007 -2.58 Aromatic amino acid beta-eliminating lyase 0.004
Cell division/sporulation/motility  
Teth39_0175 -52.70 Peptidoglycan-binding LysM 0.000
Teth39_0252 -30.04 YabP family protein 0.000
Teth39_1446 -2.42 Cell division topological specificity factor MinE 0.016
Teth39_1772 -2.33 Flagellar protein FlaG protein 0.011
Teth39_1783 -2.51 Flagellar hook-associated protein 3 0.009
Energy related   
Teth39_0466 -2.27 Thiamine pyrophosphate enzyme domain 0.038
Hydrogenase related   
Teth39_0221 -2.17 Hydrogenase with PAS/PAC sensor 0.005
Teth39_1458 -2.05 Hypothetical protein 0.005
Teth39_1459 -24.50 Histidine kinase 0.000
Hypothetical proteins   
Teth39_0794 -5.93 Hypothetical protein 0.041
Teth39_0842 -36.68 Hypothetical protein 0.000
Nucleotide related   
Teth39_1357 -2.51 Metal-dependent phosphohydrolase 0.002
Teth39_2157 -9.29 SirA family protein 0.000
Redox proteins   
Teth39_0445 -2.19 Thioredoxin reductase 0.002
Teth39_1916 -2.73 Oxidoreductase FAD/NAD(P)-binding domain 0.001
Teth39_1917 -4.88 4Fe-4S ferredoxin, iron-sulfur binding domain 0.000
Teth39_2155 -4.30 FAD-dependent pyridine nucleotide-disulfide oxidoreductase 0.000
Transcriptional regulator  
Teth39_0150 -2.56 Transcriptional regulator, DeoR family 0.011
Teth39_0757 -3.07 Putative cold-shock DNA-binding domain protein 0.029
Teth39_1109 -2.27 Sporulation transcriptional activator Spo0A 0.006
Teth39_1292 -2.06 Hypothetical protein 0.019
Teth39_1796 -2.17 Two-component transcriptional regulator, winged helix family 0.015
Transporters    
Teth39_0333 -2.98 PTS system, fructose subfamily, IIC subunit 0.001
Teth39_0334 -2.90 PTS system, fructose-specific, IIB subunit 0.019
Vitamin related   
Teth39_0787 -4.71 Lipoic acid synthetase 0.033
Other    
Teth39_0542 -2.43 Dihydroxyacetone kinase, DhaK subunit 0.006
Teth39_1065 -2.21 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668 0.024
Teth39_1216 -2.04 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase 0.011
  1. Sorted by general cellular function. Proteins in boldface are regulated greater than fivefold. Descriptions are from the National Center for Biotechnology Information.