Enrichment clustering of differentially expressed genes from RNA-seq analysis. WT and R57 were compared for constitutive differential expression of genes when grown in SD medium. Gene lists were compiled for significantly (P < 0.05) upregulated >2-fold or significantly downregulated <2-fold differentially expressed genes. Red colours represent upregulation, while blue colours represent downregulation. Darker shades represent a relatively higher confidence of enrichment score. Larger node sizes represent relatively larger numbers of differentially regulated genes associated with the given ontology category as compared to the full gene. Smaller distance between nodes denotes a higher degree of relationship between ontology categories, while thicker edge lines (green) denote a relatively higher degree of similarity between category nodes in terms of the degree of overlap between the specific gene sets they are associated with. AA, amino acid; UBL, ubiquitin-like.