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Figure 1 | Biotechnology for Biofuels

Figure 1

From: Redesigning the regulatory pathway to enhance cellulase production in Penicillium oxalicum

Figure 1

Scheme of a systematic strategy for the genetic modification of P. oxalicum. In the WT strain, the regulatory network for cellulase expression is balanced between the induction from cellobiose, which is the substrate of BGL2 and mediated by ClrB, and repression from glucose, which is the product of BGL2 and mediated by CreA (left). CreA (deletion), ClrB (over-expression), and BGL2 (deletion) were genetically engineered for the amplification of the induction and the elimination of CCR for maximizing the output of cellulase expression (right).

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