Fig. 1

Clostridial proteomic summary under metabolite stress. a Comparison of the butanol (red) and butyrate (blue) stress proteome. Comparison of proteome between non-stress control condition and b butanol stress. Comparison of proteome between non-stress control condition and c butyrate stress. Distribution of the stress proteome into various COG functional groups d butanol stress and e butyrate stress. Differential expression within COG categories f butanol stress and g butyrate stress. Red asterisks: COG category enriched with upregulated proteins; green asterisks: COG category enriched in downregulated proteins; black asterisks: COG category equally enriched in up- and downregulated proteins. C: energy production and conversion; D: cell division and chromosome partitioning; E: amino acid transport and metabolism; F: nucleotide transport and metabolism; G: carbohydrate transport and metabolism; H: coenzyme metabolism; I: lipid metabolism; J: translation, ribosomal structure and biogenesis; K: transcription; L: DNA replication, recombination, and repair; M: cell envelope biogenesis, outer membrane; N: cell motility and secretion; O: posttranslational modification, protein turnover, chaperones; P: inorganic ion transport and metabolism; Q: secondary metabolites biosynthesis, transport, and catabolism; R: general function prediction only; S: function unknown; T: signal transduction mechanisms; U: intracellular trafficking, secretion, and vesicular transport; V: defense mechanisms