Fig. 5
From: Computational inference of the structure and regulation of the lignin pathway in Panicum virgatum
Parallel reactions catalyzed by 4CL. The observed simultaneous accumulation of 4CL substrates and decrease in coniferaldehyde in COMT transgenic lines can be explained with the assumption of an inhibitory effect on the reactions catalyzed by 4CL. 5-OH-ferulic acid could be a candidate for this role. Although 5-OH-ferulic acid is not a substrate for 4CL in switchgrass, it has a similar molecular shape as ferulic acid, so that high concentrations of 5-OH-ferulic acid might exert competitive inhibition that is comparable to the inhibitory effects of ferulic acid