Table 1 Summary of the organization of the transcriptional changes

Early

0–18 min

Up

Monotonic

2, 7, 105

Ammonium transport (1.7e−9)

Potassium ion transmembrane transport (1.4e−5)

Ion channel activity (2.8e−3)

Ion transport (3.4e−3)

Protein kinase activity (1.3e−2)

Transient

2, 7, 118

Down

Monotonic

1, 1, 17

Ribosome biogenesis (6.3e−8)

Transcription (3.7e−6)

rRNA processing (2.9e−5)

Pseudouridine synthesis (7.0e−5)

Methyltransferase activity (9.0e−5)

Transient

1, 17, 202

Mid

18–60 min

Up

Monotonic

4, 24, 304

Mitochondrial pyruvate transport (1.0e−6)

Glutamine biosynthetic process (3.0e−5)

Lipid metabolic process (5.2e−5)

Amine metabolic process (7.5e−5)

Proteolysis (9.6e−3)

Transient

3, 7, 110

Down

Monotonic

4, 44, 552

Purine nucleotide biosynthetic process (5.1e−5)

Fatty acid beta-oxidation (4.9e−4)

Pseudouridine synthesis (8.7e−4)

Malate dehydrogenase activity (1.6e−3)

Fatty acid biosynthetic process (1.9e−3)

Transient

4, 15, 237

Late

1–8 h

Up

Monotonic

3, 12, 177

DNA replication (8.6e−7)

Microtubule cytoskeleton organization (1.1e−4)

NADP binding (3.5e−3)

Lipid metabolic process (1.8e−2)

Nucleotide binding (2.4e−2)

Transient

2, 8, 139

Down

Monotonic

3, 47, 489

Photosynthesis (7.7e−31)

Protein folding (1.0e−13)

Fructose-bisphosphate aldolase activity (8.4e−6)

Cell redox homeostasis (4.9e−5)

Fatty acid biosynthetic process (7.5e−3)

Transient

2, 5, 95