Table 1 ATP yield for the synthesis of products from acetyl-CoA with H2 or CO as electron donor
From: Bioenergetic constraints for conversion of syngas to biofuels in acetogenic bacteria
Product | Key enzymes/intermediates | Conversion (acetyl-CoA as precursor) | ATP yield | |
|---|---|---|---|---|
H2 | CO | |||
Acetate | Acetate kinase | Acetyl-CoA→acetate | 0.3 | 1.5 |
Ethanol | Acetaldehyde DH | Acetyl-CoA→ethanol | −0.1 | 1.7 |
| Â | AOR | Â | 0.3 | 2.1 |
Butanol | BDH | 2 acetyl-CoA→butanol | −0.2 | 3.4 |
| Â | BDH, bifurcating Bcd | Â | 0.4 | 4.0 |
| Â | AOR | Â | 0.2 | 3.8 |
| Â | AOR, bifurcating Bcd | Â | 0.8 | 4.4 |
Isoprene | Mevalonate | 3 acetyl-CoA→isoprene + CO2 | −4.5 | −0.3 |
Lactate | NADH-dependent LDH | Acetyl-CoA + CO2→lactate | −0.7 | 1.1 |
|  | Bifurcating LDH |  | −0.1 | 1.7 |
2,3-Butanediol | Acetolactate synthase | 2 acetyl-CoA→2,3-butanediol | −1.7 | 1.6 |
Acetone | Acetoacetate | 2 acetyl-CoA→acetone + CO2 | −0.4 | 2.0 |
Isobutene | Acetone, 3-OH-isovalerate | 3 acetyl-CoA→isobutene + 2 CO2 | −2.1 | 1.5 |