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Table 1 ATP yield for the synthesis of products from acetyl-CoA with H2 or CO as electron donor

From: Bioenergetic constraints for conversion of syngas to biofuels in acetogenic bacteria

Product Key enzymes/intermediates Conversion (acetyl-CoA as precursor) ATP yield
H2 CO
Acetate Acetate kinase Acetyl-CoA→acetate 0.3 1.5
Ethanol Acetaldehyde DH Acetyl-CoA→ethanol −0.1 1.7
  AOR   0.3 2.1
Butanol BDH 2 acetyl-CoA→butanol −0.2 3.4
  BDH, bifurcating Bcd   0.4 4.0
  AOR   0.2 3.8
  AOR, bifurcating Bcd   0.8 4.4
Isoprene Mevalonate 3 acetyl-CoA→isoprene + CO2 −4.5 −0.3
Lactate NADH-dependent LDH Acetyl-CoA + CO2→lactate −0.7 1.1
  Bifurcating LDH   −0.1 1.7
2,3-Butanediol Acetolactate synthase 2 acetyl-CoA→2,3-butanediol −1.7 1.6
Acetone Acetoacetate 2 acetyl-CoA→acetone + CO2 −0.4 2.0
Isobutene Acetone, 3-OH-isovalerate 3 acetyl-CoA→isobutene + 2 CO2 −2.1 1.5