Skip to main content

Advertisement

Table 2 MIPS functional catalog category classification of all the genes specifically down-regulated in the pkaA deletion strain

From: Aspergillus nidulans protein kinase A plays an important role in cellulase production

Functional category Genes p value
01 Metabolism   
 01.01 amino acid metabolism 107 0.00013
 01.01.03 assim. ammonia, metab. glutamate group 27 0.00201
 01.01.03.05 metabolism of arginine 10 0.01657
 01.01.03.05.01 biosynthesis of arginine 8 0.00840
 01.01.05 metab. urea cycle, creatine and polyamines 9 0.03639
 01.01.06.01 metabolism of aspartate 7 0.00523
 01.01.06.01.02 degradation of aspartate 5 0.01900
 01.01.06.04 metabolism of threonine 7 0.00359
 01.01.06.04.01 biosynthesis of threonine 3 0.03204
 01.01.06.05 metabolism of methionine 14 0.00040
 01.01.06.05.01 biosynthesis of methionine 7 0.02838
 01.01.06.05.01.01 biosynthesis of homocysteine 3 0.05076
 01.01.09 metabolism of the cysteine - aromatic group 43 0.02539
 01.01.11.01 metabolism of alanine 3 0.00784
 01.01.11.02 metabolism of isoleucine 10 0.00434
 01.01.11.02.01 biosynthesis of isoleucine 8 0.00331
 01.01.11.02.02 degradation of isoleucine 5 0.02647
 01.01.11.03 metabolism of valine 8 0.02220
 01.01.11.03.01 biosynthesis of valine 7 0.00523
 01.01.11.03.02 degradation of valine 5 0.03558
 01.03.01 purin nucleot/nucleoside/nucleobase metab. 33 0.00029
 01.03.07 deoxyribonucleotide metabolism 7 0.01761
 01.03.16 polynucleotide degradation 21 0.03254
 01.03.16.01 RNA degradation 14 0.02504
 01.05.13 transfer of activated C-1 groups 23 0.00011
 01.05.13.03 tetrahydrofolate-dependent C-1-transfer 7 0.00237
 01.06.06 isoprenoid metabolism 31 0.02022
 01.06.06.11 tetracyclic and pentacyclic triterpenes (cholesterin, steroids and hopanoids) metabolism 28 0.00044
 01.07 metab. vitamins, cofactors, and prosthetic groups 53 0.00514
 01.07.01 biosyn. vitam, cofactors, prosthetic groups 33 0.00305
 01.20.19 metabolism of secondary products derived from glycine, l-serine and l-alanine 12 0.00100
 01.20.19.01 metabolism of porphyrins 10 0.00134
02 Energy   
 02.07.01 pentose-phosphate pathway oxidative branch 2 0.04599
 02.08 pyruvate dehydrogenase complex 3 0.05076
 02.10 (citrate cycle, Krebs cycle, TCA cycle) 13 0.01823
 02.13 respiration 51 0.00123
 02.13.01 anaerobic respiration 6 0.00061
 02.13.03 aerobic respiration 37 0.00715
10 Cell cycle and DNA processing   
 10.01.03 DNA synthesis and replication 31 0.00080
 10.01.03.03 ori recognition, priming complex formation 8 0.00630
11 Transcription   
 11.02.01 rRNA synthesis 31 0.00153
 11.04.01 rRNA processing 89 0.00002
 11.04.03 mRNA processing (splicing, 5^-, 3^-end) 63 0.00398
 11.04.03.01 splicing 56 0.00235
 11.06.01 rRNA modification 12 0.00448
12 Protein synthesis   
 12.01 ribosome biogenesis 174 0.00004
 12.01.01 ribosomal proteins 126 0.00006
 12.04 translation 115 0.00080
 12.04.02 translation elongation 9 0.00396
 12.04.03 translation termination 3 0.03204
 12.07 translational control 23 0.00122
 12.10 aminoacyl-tRNA-synthetases 18 0.00100
14 Protein fate (folding, modification, destination)   
 14.01 protein folding and stabilization 30 0.00077
 14.04 protein targeting, sorting and translocation 59 0.00044
 14.10 assembly of protein complexes 56 0.00275
16 Protein binding function or cofactor required (structural or catalytic)
 16.03.01 DNA binding 68 0.05063
 16.07 structural protein binding 14 0.02191
 16.19.05 GTP binding 26 0.00253
 16.21 complex cofactor/cosubstrate/vitamin binding 78 0.00581
 16.21.05 FAD/FMN binding 27 0.02943
 16.21.17 pyridoxal phosphate binding 16 0.00077
20 Cel. transp., transp. facilities and transp. routes  
 20.01.01.01.01 heavy metal ion transport (Cu + , Fe3 +) 15 0.03629
 20.01.03.03 C4-transport (malate, succinate, fumarate) 6 0.00356
 20.01.21 RNA transport 16 0.01353
 20.09.01 nuclear transport 21 0.00100
 20.09.04 mitochondrial transport 48 0.00572
 20.09.16.05 Type V protein secretion system 2 0.01677
42 Biogenesis of cellular components   
 42.10.05 nuclear membrane 8 0.00231
 42.10.07 nucleolus 4 0.00028
 42.16 mitochondrion 69 0.00004