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Fig. 4 | Biotechnology for Biofuels

Fig. 4

From: Whole-genome sequence of an evolved Clostridium pasteurianum strain reveals Spo0A deficiency responsible for increased butanol production and superior growth

Fig. 4

Genetic basis of solventogenesis from glycerol in C. pasteurianum. Possible metabolic pathways for glycerol to 1,3 propanediol, ethanol and butanol. Gene names coding for the enzymes catalyzing the corresponding reactions are listed in italics. Multiple genes coding for a complexed functional protein are colored blue. Paralogs annotated with the same function and name are noted in parentheses. Asterisks indicate genes found mutated in M150B. Enzyme names are as follows: 1 glycerol dehydratase, 2 1,3-propanediol dehydrogenase, 3 glycerol dehydrogenase, 4 dihydroxyacetone kinase, 5 triosephosphate isomerase, 6 glyceraldehyde-3-phosphate dehydrogenase, 7 phosphoglycerate kinase, 8 phosphoglycerate mutase, 9 enolase, 10 pyruvate kinase, 11 pyruvate-flavodoxin oxidoreductase, 12 acetyl-CoA acetyltransferase, 13 3-hydroxybutyryl-CoA dehydrogenase, 14 3-hydroxybutyryl-CoA dehydratase, 15 butyryl-CoA dehydrogenase/Etf complex, 16 butyrate-acetoacetate CoA-transferase, 17 aldehyde-alcohol dehydrogenase, 18 possible pyruvate decarboxylase, 19 NADH-dependent butanol dehydrogenase, 20 NADPH-dependent butanol dehydrogenase, 21 phosphate acetyltransferase, 22 acetate kinase, 23 phosphate butyryltransferase, 24 butyrate kinase

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