Elucidation of the roles of adhE1 and adhE2 in the primary metabolism of Clostridium acetobutylicum by combining in-frame gene deletion and a quantitative system-scale approach

Table 2 Numbers of significantly changed genes by each gene deletion and genes exhibiting the same pattern of change for both deletions under three different metabolic states (the genes exhibiting the same pattern for both deletions under acidogenesis are listed in Table 3)

	ΔadhE1	ΔadhE2	Same pattern in ΔadhE1 and ΔadhE2	Note^a
Up-regulation under acidogenesis	100	119	50	Most CymR regulons are included
Down-regulation under acidogenesis	108	170	89	Most butanol response genes are included
Up-regulation under solventogenesis	55	22	0
Down-regulation under solventogenesis	127	17	1	CA_C3612
Up-regulation under alcohologenesis	1	35	0
Down-regulation under alcohologenesis	14	38	1	CA_C3274

^aRepresentative features or locus number of the sole gene showing same pattern under certain condition are shown

ISSN: 2731-3654