Fig. 6

Expression levels of individual genes. On y-axis the average gene expression level expressed as rlog2 which is log2 like transformation of normalized counts calculated by DESeq2 [40]. On x-axis time points (16–64 h) from the cultivations of the six strains. a main cellulases of T. reesei. b Central genes of protein secretion. c Selected differentially expressed regulators. d Heterologous product genes cutinase (Cut) and lipase (Lip). Main cellulase signal in cellulase deletion strain Cel4d is a technical artefact created by the DESeq2 process as exemplified by its lack of variation in Cel4d samples