Fig. 1

Identified residues which might affect the substrate specificity of cADO (PDB code: 4RC5). The identified residues include those close to the aldehyde group (Gly31 and Ala118) and the hydrophobic tail (Tyr21 and Cys70) of the substrate, and those along the substrate channel (Ile24, Ile27, Val28, Phe87, Ala121, Val184, Met193 and Leu198). The bound substrate analog was colored yellow