Fig. 8From: Exploring complex cellular phenotypes and model-guided strain design with a novel genome-scale metabolic model of Clostridium thermocellum DSM 1313 implementing an adjustable cellulosomeProposed mechanism of bioenergetics influencing C. thermocellum during growth on cellulosic substrates. Motif 1: cellobiose inhibits cellulosome production, and the lower ATP requirement reduces the need for PTA-ACK. Motif 2: redox metabolism is restructured such that RNF activity is upregulated and/or BIF activity is downregulated to convert more reduced ferredoxin to NADH. Motif 3: the regulation of PEP to pyruvate is affected by PPi concentrations, and increased RNF activity can be used to synthesize PPi. Motif 4: PFL acts as a redox relief valve and is likely activated by a redox imbalanceBack to article page