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Fig. 7 | Biotechnology for Biofuels

Fig. 7

From: Furfural tolerance and detoxification mechanism in Candida tropicalis

Fig. 7

Mechanism of furfural tolerance and metabolic responses to furfural in C. tropicalis. Alcohol dehydrogenase 1 catalyzes the reduction of furfural and acetaldehyde with NADH as coenzyme. The green arrow represents that the transcription of ctADH1 is induced by furfural, and furfural could be degraded by alcohol dehydrogenase 1 (encoded by ctADH1). The process of furfural degradation causes the imbalance of NADH/NAD+ ratio (Fig. 5). After furfural depletion, alcohol dehydrogenase 1 left in cells unavoidably produces ethanol. The red arrow represents that the transcription of ctADH1 is repressed by ethanol to decrease ethanol production and NADH consumption. The repression of ctADH1 contributes to maintain the redox balance

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