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Fig. 2 | Biotechnology for Biofuels

Fig. 2

From: Efficient estimation of the maximum metabolic productivity of batch systems

Fig. 2

Elementary Flux Mode Surfaces. Projections of the yield surfaces are shown for the 3D yield surface of A. succinogenes (a) and 4D surface of E. coli (b). Elementary flux modes are normalized by glucose uptake, and therefore points in yield space represent the amount of product (in mols) which can be produced from 1 mol of glucose. Modes which lie along the Pareto-optimal surface are highlighted in red, and the convex hull spanned by these points is shaded gray. For A. succinogenes, in which succinate production is coupled to optimal growth, the Pareto frontier of succinate vs. biomass yield is sharply curved. Compared with the corresponding plot in E. coli, this shape suggests that higher succinate production can be achieved in A. succinogenes without a linear penalty in growth and ATP yield. The entire flux cone need not be spanned by the selected EFMs, as demonstrated by the lack of high oxygen consuming—low ATP-producing EFMs selected for the E. coli network

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