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Table 2 Comparison of process performance indicators using reference and optimized media. Error bars represent min/max from biological replicates (n = 2)

From: A framework for accelerated phototrophic bioprocess development: integration of parallelized microscale cultivation, laboratory automation and Kriging-assisted experimental design

Parameter enBBMref enBBMopt
Exponential growth rate (d−1) 1.49 ± 0.06 1.45 ± 0.1
Time to nitrate depletion (h) 84 52
Delay from nitrate depletion to onset of lipid synthesis [h] 36 20
Biomass-specific lipid accumulation rate [% (w w−1) d−1] 4.87 ± 0.53 6.43 ± 0.17
Cell dry weight at harvest (g L−1) 4.95 ± 0.06 4.93 ± 0.01
Neutral lipid content at harvest [% (w w−1)] 10.55 ± 0.35 23.9 ± 1.2
Volumetric productivity (mg L−1 d−1) 74 ± 1 169 ± 7