Fig. 6
a A conceptual model illustrating the interactions between C. cellulovorans (CC) and M. mazei (MM) in cocultures. The key pathways of the interactions are highlighted. The final products of the metabolic pathways are also shown in order to describe the carbon and cellular metabolism in the coculture model. Red and blue color lines represent the upregulated and downregulated pathways, respectively. Green color highlights the resulting effects of cocultivation of CC with MM. b Upregulated (red) and downregulated (blue) expression profiles of selected genes (|fold change| ≥1.2 and p value <0.05) of CC and MM related to the key pathways of the interactions at mid-exponential growth phase. The abbreviations are NADH, reduced form of nicotinamide adenine dinucleotide; NAD+, oxidized form of nicotinamide adenine dinucleotide; Hyd, hydrogenase; Fdrex, reduced form of ferredoxin; Fdox, oxidized form of ferredoxin; PFOR, pyruvate:ferredoxin oxidoreductase; Acetyl-CoA, acetyl coenzyme A; Acetyl-P, acetyl phosphate; ATP, adenosine triphosphate; ADP, adenosine diphosphate; HS-CoA, coenzyme A; Formyl-MFR, a formyl-methanofuran; Formyl-H4MPT, 5-formyl-tetrahydromethanopterin; Methenyl-H4MPT, 5,10-methenyltetrahydromethanopterin; Methylene-H4MPT, 5,10-methylene-tetrahydromethanopterin; Methyl-H4MPT, 5-methyl-tetrahydromethanopterin; Methyl-H4SPT, 5-methyl-tetrahydrosarcinapterin; CH3-Co(III)FeSP, a methylated corrinoid Fe-S protein; MCR, methyl-coenzyme M reductase