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Table 3 The maximum growth rate (μ max) and nerolidol productivities of the engineered strain in flask cultivation on 20 g L−1 glucose

From: Coupling gene regulatory patterns to bioprocess conditions to optimize synthetic metabolic modules for improved sesquiterpene production in yeast

Strain N6D NC1D N391DA
μ max (h−1) 0.16 ± 0.03 0.25 ± 0.01 0.27 ± 0.01
r nerolidol (0–24 h; mg g−1 biomass h−1) 5.73 ± 2.19 5.14 ± 1.29 1.40 ± 0.05
r nerolidol (24–72 h; mg g−1 biomass h−1) 0.18 ± 0.08 0.77 ± 0.09 2.10 ± 0.02
Nerolidol titre (72 h; mg L−1) 124 ± 29 245 ± 8 393 ± 3
Nerolidol C-mole yield (%) 1.7 ± 0.4 3.3 ± 0.1 5.0 ± 0.3
  1. Mean values ± standard deviations are shown (N ≥ 2)
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