Systems analysis of ethanol production in the genetically engineered cyanobacterium Synechococcus sp. PCC 7002

Table 2 Correlation analysis of the variation of the 3PGA pool compared to all monitored metabolites of this study

Metabolite	Pearson’s correlation coefficient (r) of normalized responses
Metabolite	All samples	Wild type	Producer
Positive correlation
Glyceric acid-3-phosphate	1.000	1.000	1.000
Glyceric acid-2-phosphate	0.806	0.767	0.450
Glutamic acid	0.821	0.755	0.557
Glutamine (pyroglutamic acid, glutamate)^a	0.810	0.727	0.689
Glutamic acid, N-acetyl-	0.821	0.712	0.676
A112003	0.716	0.789	0.718
Negative correlation
Mannose	0.408	−0.956	−0.615
Glucose	0.112	−0.774	−0.557
Fructose	0.068	−0.760	−0.640
Phenylalanine	0.011	−0.700	−0.642
A214003	0.224	−0.733	−0.718
A311002	−0.159	−0.732	−0.498

Pearson’s correlation coefficient of the WT subset were ranked and filtered by r > 0.70 or r < −0.70
Correlation coefficients of normalized responses from all, WT, or producer samples are reported. The complete data set can be found in Additional file 1
^aPyroglutamic acid represents the sum of the glutamine, pyroglutamic and glutamic acid pool

ISSN: 2731-3654