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Fig. 4 | Biotechnology for Biofuels

Fig. 4

From: A new genome-scale metabolic model of Corynebacterium glutamicum and its application

Fig. 4

Application for overproduction of the non-natural products 1,2-propanediol (a) and isobutanol (b) using OptForceMUST. Genes encoding relevant enzymes are depicted with italics next to the arrows: aceE: pyruvate dehydrogenase complex; adhA: alcohol dehydrogenase; alaS: acetolactate synthase; gap: glyceraldehyde-3-phosphate dehydrogenase; gldA: glycerol dehydrogenase; gpmA: phosphoglycerate mutase; hdpA: dihydroxyacetone phosphate phosphatase; ilvC: acetohydroxyacid isomeroreductase; ilvD: dihydroxyacid dehydratase; ilvE: valine transaminase; kivD: keto acid decarboxylase; ldh: lactate dehydrogenase; mgsA: methylglyoxal synthase; pgi: glucose-6-phosphate isomerase; pgk: phosphoglycerate kinase; tpiA: triose-phosphate isomerase; yqhD: aldehyde reductase. For other genes, see Fig. 3. 12ppd: 1,2-propanediol; 13dpg: 3-phospho-d-glyceroyl phosphate; 23dhmp: 2,3-dihydroxy-3-methylbutanoate; 2pg: d-glycerate 2-phosphate; 3mob: 3-methyl-2-oxobutanoate; 3pg: 3-phospho-d-glycerate; 6pgl: 6-phospho-d-glucono-1,5-lactone; acetol: acetol; alas-S: 2-acetolactate; dha: dihydroxyacetone; dhap: dihydroxyacetone phosphate; ibth: isobutyraldehyde; isob: isobutanol; l-lac: l-lactate; mthgxl: methylglyoxal; l-val: l-valine. For other abbreviations, see Fig. 3

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