Fig. 2

Comparison of the simulation results with experimental data for wild-type E. coli. Micro-aerobic (a) and aerobic (b) conditions. The experimental data for micro-aerobic and aerobic conditions refer to those reported by Zhu and Shimizu [42] and Toya et al. [41], respectively. The DO levels were set to 1 and 40% for the simulation under micro-aerobic and aerobic conditions, respectively, where these conditions are comparable to the experimental conditions. The simulation results show the product concentrations at the time points at which 10 g/l (micro-aerobic) and 4 g/l (aerobic) of glucose were depleted in the batch cultures