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Table 1 Comparison of IBE production using wild-type or genetically modified solventogenic Clostridium species

From: Enhanced isopropanol–butanol–ethanol mixture production through manipulation of intracellular NAD(P)H level in the recombinant Clostridium acetobutylicum XY16

Bacterium Substrate Metabolic products (g/L) Solvent yield (g/g) Ref.
C. beijerinckii NRRL B-593 Glucose 60 g/L Isopropanol (2.16)
Butanol (3.71)
0.21 [26]
C. beijerinckii NRRL B-593 Glucose 60 g/L Isopropanol (1.85)
Butanol (8.13)
Ethanol (2.22)
0.33 [28]
Clostridium sp. NJP7 Glucose 60 g/L Acetone (2.21)
Isopropanol (1.92)
Butanol (12.21)
0.24 [22]
C. acetobutylicum 824 PJC4BK (pIPA3-Cm2) Glucose 132.9 g/L Isopropanol (4.4)
Butanol (14.1)
Ethanol (1.9)
0.2 [4]
C. acetobutylicum 824 BKM19 (pIPA100) Glucose 76 g/L Isopropanol (3.5)
Butanol (15.4)
Ethanol (9.6)
0.38 [29]
C. acetobutylicum 824 Δbuk pCLF952 Glucose 63.5 g/L Acetone (0.36)
Isopropanol (4.75)
Butanol (14.63)
Ethanol (1.01)
0.33 [30]
C. acetobutylicum XY6 (pSADH) Glucose 60 g/L Isopropanol (6.02)
Butanol (10.51)
Ethanol (1.24)
0.31 This study