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Table 5 Comparison of 2,3-BD production in various microorganisms

From: Production of (2R, 3R)-2,3-butanediol using engineered Pichia pastoris: strain construction, characterization and fermentation

Species Titer (g/L) Operation strategy Enantiopurity (%) Yield (g/g) Feed stock 2,3-BD productivity (g/L/h) References
S. cerevisiae 43.6 Fed-batch 97 0.27 Xylose 0.15 [12]
S. cerevisiae 96.2 Fed-batch NA 0.28 Glucose 0.39 [11]
S. cerevisiae 154.3 Fed-batch NA 0.404 Glucose 1.97 [35]
S. cerevisiae 100 Fed-batch 98 0.35 Glucose and galactose 0.33 [14]
E. coli 6.9 Shake flask 99 0.31 Glucose 0.14 [36]
E. coli 73.8 Fed-batch NA 0.41 Glucose 1.19 [30]
E. coli 115 Fed-batch 99 0.42 Glucose 1.44 [9]
E. aerogenes 152 Fed-batch 97.5 0.489 Glucose and xylose 3.5 [37]
E. aerogenes 140 Fed-batch NA NA Sugarcane molasses 2.59 [38]
B. subtilis 49.29 Shake flask 99 0.47 Glucose 0.224 [4]
B. subtilis 130.7 Fed-batch 99 0.487 Glucose 0.459 [39]
B. licheniformis 123.7 Fed-batch 99 NA Glucose 2.95 [6]
B. amyloliquefaciens 132.9 Fed-batch NA 0.45 Glucose 2.95 [40]
K. oxytoca 131.5 Fed-batch NA 0.44 Crude glycerol 0.84 [41]
K. oxytoca 117.4 Fed-batch NA 0.49 Glucose 1.2 [42]
K. pneumoniae 150 Fed-batch NA NA Glucose 4.21 [43]
S. marcescens 152 Fed-batch NA 0.463 Sucrose 2.67 [44]
P. polymyxa 36.92 Batch 98   Raw inulin extract 0.88 [8]
C. glutamicum 6.3 Batch NA 0.33 Glucose 0.2 [45]
Z. mobilis 15 Batch NA 0.16 Glucose, xylose 0.3 [46]
P. pastoris 75 Fed-batch 99 0.3 Glucose 0.81 This study