Alignment of microbial fitness with engineered product formation: obligatory coupling between acetate production and photoautotrophic growth

Table 2 Metabolites that can be produced in a growth-coupled way based on in silico simulations

Metabolite	Growth rate (h⁻¹)	Yield (mmol gDW⁻¹)	Gene knockouts
5-Methylthioadenosine	0.052	0.007	sll0135
Acetate	0.052	0.195	sll0542, sll1299
Mercaptopyruvate	0.034	5.702	sll1027 or sll1502, slr0710, sll1499
5′-Deoxyadenosine	0.052	0.044	sll1185
3,4-Dihydroxy-2-butanone 4-phosphate	0.051	0.732	sll0753, sll0330, sll1556
Adenine	0.052	0.032	sll1430
Adenosine	0.052	0.032	sll1430
S-Adenosyl-l-homocysteine	0.052	0.025	sll1758
Fumarate	0.051	0.848	slr0018
	0.044	3.162	slr0018, slr0458, sll1349
	0.043	3.509	slr0018, slr0458, sll1349, slr1755

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