TY - JOUR AU - Martin, Caterina AU - Ovalle Maqueo, Amaury AU - Wijma, Hein J. AU - Fraaije, Marco W. PY - 2018 DA - 2018/03/01 TI - Creating a more robust 5-hydroxymethylfurfural oxidase by combining computational predictions with a novel effective library design JO - Biotechnology for Biofuels SP - 56 VL - 11 IS - 1 AB - HMF oxidase (HMFO) from Methylovorus sp. is a recently characterized flavoprotein oxidase. HMFO is a remarkable enzyme as it is able to oxidize 5-hydroxymethylfurfural (HMF) into 2,5-furandicarboxylic acid (FDCA): a catalytic cascade of three oxidation steps. Because HMF can be formed from fructose or other sugars and FDCA is a polymer building block, this enzyme has gained interest as an industrially relevant biocatalyst. SN - 1754-6834 UR - https://doi.org/10.1186/s13068-018-1051-x DO - 10.1186/s13068-018-1051-x ID - Martin2018 ER -