Metabolome- and genome-scale model analyses for engineering of Aureobasidium pullulans to enhance polymalic acid and malic acid production from sugarcane molasses

Table 1 PMA production from various biomass substrates by different strains of A. pullulans

Microorganism	Substrates	Nitrogen sources	Operating mode	PMA^a (g/L)	Malic acid (g/L)	Productivity^a (g/L h)	Yield^a (g/g)	References
NRRL 50383	Corn fiber	Peptone and yeast extract	Batch	10.1	11.7^b	0.07	–	[13]
NRRL 50383	Wheat straw	Peptone and yeast extract	Batch	23.5	27.1^b	0.16	–	[13]
ZX-10	Soybean hull hydrolysate	Corn steep liquor	Fed-batch	27.2	31.3	0.48	0.42	[12]
	Soy molasses	–	Fed-batch	62.6	71.9	0.29	0.69
	Sugarcane juice	–	Batch	52.6	60.8	0.32	0.62	[49]
CCTCCM2012223	Hydrolysate of raw sweet potato	NH₄NO₃	Batch	29.6	33.6	0.28	0.31	[9]
CCTCCM2012223	Hydrolysate of raw sweet potato	NH₄NO₃	Fed-batch	44	49.9	0.31	0.22	[9]
YJ 6-11	Corncob hydrolysate	NH₄NO₃	Batch	28.6	32.4	0.45	0.41	[33]
FJ-PYC	Sugarcane molasses	–	Batch	31.5	36.5	0.61	0.44	This study
FJ-PYC	Sugarcane molasses	–	Fed-batch	81.5	94.2	0.67	0.62	This study

-, none or not reported
^aTo facilitate comparisons, PMA yield and productivity were based on the malic acid that can be released from PMA after hydrolysis, PMA (g/L) = 0.87 malic acid (g/L)
^bCalculated from data in this study

ISSN: 2731-3654