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Table 4 Mutations commonly observed in isolates of the evolved strain

From: A pyruvate carbon flux tugging strategy for increasing 2,3-butanediol production and reducing ethanol subgeneration in the yeast Saccharomyces cerevisiae

Chromosome

Coordinate

ORFs

Position (bp)

Mutation

Type

Evo44

Evo122

Chr 2

27308

YBL101C (ECM21)

991

T → – (deletion)

Frame shift

nd

+

Chr 3

253645

YCR079W (PTC6)

804

C → T

Synonymous

nd

+

Chr 5

288490

tS(UGA)E (SUP19)

35

G → C

–

nd

+

Chr 10

148840

YJL141C (YAK1)

1547

A → T (D516V)

Nonsynonymous

+

+

Chr 15

756954

YOR221C (MCT1)

605

G → A (G202D)

Nonsynonymous

+

+

  1. nd not detected