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Table 1 Summary of SA fermentation at different pH via metabolic evolution

From: Efficient metabolic evolution of engineered Yarrowia lipolytica for succinic acid production using a glucose-based medium in an in situ fibrous bioreactor under low-pH condition

pH Batch number Glucose consumption rate (g/L/h) Relative specific growth ratea (100%) SA titer (g/L) SA productivity (g/L/h) SA yield (g/g) Pyruvate (g/L) Acetate (g/L)
6 1–8 1.46 ± 0.18 144 ± 22 20.0 ± 0.7 0.44 ± 0.04 0.30 ± 0.03 2.5 ± 0.2 15.7 ± 1.6
5 9–16 1.05 ± 0.57 87 ± 56 18.7 ± 1.2 0.36 ± 0.14 0.24 ± 0.01 6.7 ± 0.2 3.2 ± 0.6
4 17–21 2.33 ± 0.21 131 ± 34 21.1 ± 1.2 0.67 ± 0.05 0.29 ± 0.02 5.9 ± 0.2 N.D
3 22–28 1.82 ± 0.11 90 ± 19 19.7 ± 0.5 0.49 ± 0.02 0.27 ± 0.01 1.0 ± 0 N.D
Without control (i.e. 2.1–2.5) 29–31 2.18 ± 0.05 177 ± 7 7.4 ± 0.7 0.20 ± 0.02 0.09 ± 0.01 1.0 ± 0.1 N.D
  1. aThe relative specific growth rate was calculated by setting the specific growth rate of the first batch (0.18 h−1) as 100%