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Fig. 2 | Biotechnology for Biofuels

Fig. 2

From: Current advance in bioconversion of methanol to chemicals

Fig. 2

Strategies to enhance the metabolic flux from methanol to metabolites. Methanol is first oxidized to formaldehyde by peroxisomal enzyme alcohol oxidase, which is assimilated via the xylulose 5-phosphate pathway (XuMP) (red lines). Formaldehyde dissimilation pathway is blocked (purple line). The regeneration of xylulose 5-phosphate is improved by overexpressed genes of pentose phosphate pathway (green lines). Enzymes: Aod, alcohol oxidase; Cta, catalase; Das, dihydroxyacetone synthase; Dak, dihydroxyacetone kinase; Tkt, transketolase; Fba, fructose-bisphosphate aldolase; Pfk, phosphofructokinase; Fbp, fructose bisphosphatase; Pgi, phosphoglucose isomerase. Metabolites, DHA, dihydroxyacetone; DHAP, dihydroxyacetone phosphate; GAP, glyceraldehyde 3-phosphate; F6P, fructose 6-phosphate; FBP, fructose 1,6-bisphosphate; Xu5P, xylulose 5-phosphate; E4P, erythrose 4-phosphate; G6P, glucose 6-phosphate

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