Mechanism and enhancement of lipid accumulation in filamentous oleaginous microalgae Tribonema minus under heterotrophic condition

Table 3 Overview of the differentially produced intracellular metabolites detected in T. minus under photoautotrophic and heterotrophic conditions

Class	Compounds	VIP	P value	log2_FC (heterotrophic/photoautotrophic)
Amino acid	l-Alanine	2.81	0.000189	2.69
	l-Proline	2.24	0.003812	0.96
	Phenylgycine	1.57	0.012838	0.71
	Homoserine	3.14	0.000475	1.29
	l-Histidine	2.41	0.00208	− 1.62
	l-Glutamine	4.91	8.58E−05	+ 1.62
	l-(−)-Tyrosine	3.88	0.004852	− 1.24
	l-(+)-Lysine	5.16	7.57E−05	− 1.74
	l-Phenylalanine	3.15	0.000252814	+ 0.35
	l-Tryptophan	3.88	0.002038562	− 1.23
	Citrate	2.49	0.0029875	− 0.85
	Succinate	3.27	0.00165524	− 1.06
	Trans-4-hydroxy-l-proline	1.09	0.001132	− 1.71
Alcohols	d-Mannitol	2.03	0.007543	− 1.41
Alcohols	Dulcitol	3.72	0.002039	− 1.31
Carbohydrate	Fructose 6-phosphate	1.96	0.001094	1.34
Carbohydrate	Glucose 6-phosphate	1.18	3.14E−05	1.15
Organic acid	dl-Pipecolinic acid	2.28	0.00292	− 1.47
Organic acid	5-Aminolevulinate	1.27	0.000222	− 1.88
Lipid	Lyso PC16:0	1.64	0.01795	− 1.36
	LysoPC 16:2	2.81	0.04581	− 0.62
	Lyso PC 18:0	3.50	0.023243	− 1.66
	Lyso PC18:1	5.09	0.012256933	2.80
	Lyso PC18:2	5.91	0.001855198	− 1.67
	Lyso PS:20:0	4.11	0.025835	1.87
	Lyso PC:20:4	1.23	0.036285	− 2.29
Others	Phenolamides	1.08	0.005677	0.19
	Piperidine	1.28	0.010741	1.13
	N-Methyltyramine	1.13	0.025641	0.66
	Diosgenin	3.84	0.022532	0.62
	N-Acetylneuraminic acid	2.23	0.00182	− 1.72
	l-Methionine sulfone	2.99	0.027101	− 0.99
	2,6-Diethylaniline	1.00	0.001118	1.32
	p-Chlorophenoxyacetate	2.57	0.017218	− 2.78

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