Products | Substrates | Strains | Main strategies | Titers | Yields | References |
---|---|---|---|---|---|---|
p-Hydroxybenzoic acid | p-Coumaric acid | Engineered Burkholderia glumae BGR1 | Delete genes encoding p-hydroxybenzoate-3-hydroxylase, benzoyl-CoA ligase; overexpress p-hydroxcinnmaoyl-CoA synthetase II | 2.73Â g/L | 99.0% mol/mol | [69] |
Pyrogallol, GA | Syringic acid | Engineered E. coli | Co-express desA, ligM and a GA decarboxylase gene | 7.3Â mg/L pyrogallol, 18Â mg/L GA | 7.3Â mg pyrogallol/g syringate, 18Â mg GA/g syringate | [117] |
Vanillin | 2.5% Wheat straw lignocellulose | R. jostii | Delete vdh gene | 96 mg/L | – | [131] |
Vanillin | Lignin extracted from wheat straw | Shewanella putrefaciens | Construct a microbial fuel cell system for lignin depolymerization | 275 mg/L | – | [132] |
Pyruvate | p-Coumaric acid | P. putida KT2440-CJ122 | Choose protocatechuic acid meta-cleavage pathway for p-coumaric acid conversation | – | 0.414 g/g | [135] |
Lactic acid | p-Coumaric acid | P. putida KT2440-CJ122 | Choose protocatechuic acid meta-cleavage pathway for p-coumaric acid conversation | – | 0.411 g/g | [135] |
Pyruvate | p-Coumaric acid | P. putida KT2440-CJ124 | Choose protocatechuic acid ortho-cleavage pathway for p-coumaric acid conversation | – | 0.019 g/g | [135] |
Lactic acid | p-Coumaric acid | P. putida KT2440-CJ124 | Choose protocatechuic acid ortho-cleavage pathway for p-coumaric acid conversation | – | 0.145 g/g | [135] |
Methane | Hydrolysis lignin | Anaerobic microorganisms | Degrade lignin by anaerobic digestion in a nylon bag | Â | 125Â mL methane/g volatile solid | [136] |