Oxidative damage of ScLPMO10C (CelS2). Analysis of protein oxidation by proteomics techniques has demonstrated that a family AA10 LPMO from the actinobacterium Streptomyces coelicolor, ScLPMO10C, exposed to protein inactivating conditions (presence of a reducing agent, but no substrate) is oxidized in and near the active site, predominantly on the catalytic histidines H35 (at the N terminus) and H144. The color code highlights the degree of oxidation: high (red), middle (orange) and low (yellow). For aromatic residues shown as gray sticks, no modification was detected. The grey cellulose fibril indicates the side of the protein where substrate will bind. The copper ion is shown as an orange sphere. The PDB code for ScLPMO10C is 4OY7.