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Table 5 Response Optimizer applied to optimize growth and ethanol responses at low concentrations of inhibitors added to SD-medium

From: Statistical prediction of interactions between low concentrations of inhibitors on yeast cells responses added to the SD-medium at low pH values

Parameters Goals Minimum Medium Maximum
Ethanol (g/L) Maximal 50 65 65
Biomass (mg/mL) Maximal 12 13 13
Global solutions
 Formic acid = 3.3 mml/L
 Levulinic acid = 21.6 mml/L
 Furfural = 6.6 mml/L
Predicted responses Obtained responses    
Ethanol = 70.1 ± 1 g/L Ethanol = 72.6 ± 1.0 g/L    
Biomass = 13.1 ± 1 mg/mL Biomass = 13.2 ± 0.1 mg/mL    
Global desirability = 1.000
  1. SD-medium containing 18% glucose, 2% yeast extract, 10 mg/ml of initial yeast cell in the presence of biomass inhibitors during 6 h fermentation times