Fig. 6From: Enhanced acetic acid stress tolerance and ethanol production in Saccharomyces cerevisiae by modulating expression of the de novo purine biosynthesis genesHypothesis on the mechanisms of enhanced tolerance to multiple inhibitors by overexpression of the ADE genes. Zinc ion addition upregulates transcription level of the ADE genes under acetic acid stress condition through transcription factors, including Zap1p, Bas1p, and others. Elevated transcription of the ADE genes results in enhanced adenine-nucleotide pool, higher antioxidant capacity, and improved GABA content, which contribute to enhanced tolerance to inhibitorsBack to article page