Fig. 2

Influence of high glucose feeding on cell growth and the co-production of SCO and GA. The solid symbols represent the control group of mineral salt medium fermentation, in which 50 g/L of glucose was used as carbon source at the beginning, then up to 90 g/L of glucose was fed every day. The hollow symbols represent the group of high glucose fermentation, in which 90 g/L of glucose was used for cell growth at the beginning and then a fed-batch fermentation by feeding glucose up to 150 g/L every day was carried out. Triangles represent cell growth, diamonds represent gluconic acid production, and dots represent SCO accumulation. The fermentation was also carried out in a 2.5 L bioreactor with 1.2 L fermentation volume, and the cultivation condition was similar to that done previously